Sensitivity of syngeneic tumor models to focal radiation

Date: 2017

Authors: Sarah Krueger, Kevin Guley, Chris Bull, Sumi Urs, Alden Wong, Dan Saims, Scott Wise, and Maryland Rosenfeld Franklin

29th AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics

Use of image-guided focal irradiation is a mainstay of human cancer treatment.
Image guidance allows for highly conformal treatment plans that minimize normal tissue toxicity and systemic response.
With the advent of image-guided small animal irradiators such as the Small Animal Radiation Research Platform (SARRP; Xstrahl Inc., Suwanee, GA), targeted focal irradiation can now be utilized in a broad range of preclinical oncology models.
Of particular interest is the possible use of focal irradiation to broaden the efficacy and response duration of immuno-oncology therapy.
Here we identified base-line response of several syngeneic mouse models to focal irradiation therapy.

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