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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
Videos & Webinars
Drug-Drug Interactions: Understanding Proposed FDA Regulations and Applying In Vitro and Physiologically Based Modeling Techniques
As the population ages, approximately 33 percent of patients are considered polypharmacy, taking multiple drugs at the same time (Bjerrum, Gonzalez Lopez-Valcarcel et al. 2008). The percentage of the population taking at least five different medications increases from 25 percent to 46 percent as the population ages from age 65 to 79 (Charlesworth, Smit et al. 2015). Based on these statistics, it is not a surprise that many patients have experienced a problem with how drugs or other substances (like coffee) interact in their body. It's the responsibility of drug developers to understand how a potential new substance will interact with other drugs. In this webinar, speakers review the proposed changes to the FDA regulatory guidance to ensure that the appropriate data are being captured in your drug development program, explore what else can be done with data to better understand enzymes, transporters and drug disposition, and present case studies demonstrating the use of PBPK models to simulate potential exposure changes of both the victim and perpetrator compounds and discuss how these results can be used in regulatory conversations and how they can help you design additional experiments to optimize your program.
